Calcitonin gene–related peptide inhibits angiotensin II–mediated vasoconstriction in human radial arteries: Role of the Kir channel

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Zulli, Anthony, Ye, Bei, Wookey, Peter J, Buxton, Brian F and Hare, David L (2008) Calcitonin gene–related peptide inhibits angiotensin II–mediated vasoconstriction in human radial arteries: Role of the Kir channel. Journal of Thoracic and Cardiovascular Surgery, 136 (2). pp. 370-375. ISSN 0022-5223

Abstract

The radial artery is increasingly used for coronary artery bypass grafts, but its potential for spasm increases postoperative risk. Alpha-calcitonin gene–related peptide is a potent antihypertensive peptide. Thus, we set out to determine whether calcitonin gene–related peptide can impair angiotensin II–mediated vasoconstriction in human radial arteries and, if so, to determine its mechanism of action.

Item type Article
URI https://vuir.vu.edu.au/id/eprint/4106
Official URL http://jtcs.ctsnetjournals.org/cgi/content/abstrac...
Subjects Historical > FOR Classification > 1102 Cardiorespiratory Medicine and Haematology
Historical > FOR Classification > 1101 Medical Biochemistry and Metabolomics
Historical > Faculty/School/Research Centre/Department > School of Biomedical and Health Sciences
Keywords ResPubID17594, ResPubID22030. peptides, angiotensin II, vasoconstriction, human radial arteries, Kir channel, calcitonin gene–related peptide, coronary artery bypass grafts
Citations in Scopus 5 - View on Scopus
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