Calming the (Cytokine) storm: Dimethyl fumarate as a therapeutic candidate for covid-19

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Timpani, Cara ORCID: 0000-0003-4567-4319 and Rybalka, Emma ORCID: 0000-0002-4854-0036 (2021) Calming the (Cytokine) storm: Dimethyl fumarate as a therapeutic candidate for covid-19. Pharmaceuticals, 14 (1). pp. 1-15. ISSN 1424-8247 (In Press)

Abstract

COVID-19 has rapidly spread worldwide and incidences of hospitalisation from respiratory distress are significant. While a vaccine is in the pipeline, there is urgency for therapeutic options to address the immune dysregulation, hyperinflammation and oxidative stress that can lead to death. Given the shared pathogenesis of severe cases of COVID-19 with aspects of multiple sclerosis and psoriasis, we propose dimethyl fumarate as a viable treatment option. Currently approved for multiple sclerosis and psoriasis, dimethyl fumarate is an immunomodulatory, anti-inflammatory and anti-oxidative drug that could be rapidly implemented into the clinic to calm the cytokine storm which drives severe COVID-19.

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Item type Article
URI https://vuir.vu.edu.au/id/eprint/42094
DOI https://doi.org/10.3390/ph14010015
Official URL https://www.mdpi.com/1424-8247/14/1/15
Subjects Historical > FOR Classification > 0601 Biochemistry and Cell Biology
Historical > FOR Classification > 1109 Neurosciences
Current > Division/Research > Institute for Health and Sport
Keywords severe acute respiratory syndrome coronavirus type-2, SARS-CoV-2, COVID-19 pandemic, Dimethyl fumarate, DMF, approved drug, immunomodulatory properties, anti-oxidative properties, anti-inflammatory properties, hyperinflammation
Citations in Scopus 12 - View on Scopus
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