Yeast Glycogen Synthase Kinase-3β Pathway Inhibitors from an Organic Extract of Streptomyces sp.

Full text for this resource is not available from the Research Repository.

Cheenpracha, Sarot, Zhang, Hao Lan, Mar, Anne M. N, Foss, Adam P, Foo, Sek Hin, Lai, Ngit Shin, Jee, Jap Meng, Seow, Heng-Fong, Ho, Coy Choke and Chang, Leng Chee (2009) Yeast Glycogen Synthase Kinase-3β Pathway Inhibitors from an Organic Extract of Streptomyces sp. Journal of Natural Products, 72 (8). pp. 1520-1523. ISSN 0163-3864

Abstract

Investigation of a microbial fermentation organic extract of Streptomyces sp. H7667 led to the isolation of three new imides, 3-[(5E)-5-methyl-4-oxo-2-hydroxy-5-octenyl]glutarimide (1), 2-amino-N-2′-(phenylacetyl)propanimide (5), and 2-amino-N-(2′-(cyclohex-2′′-enyl)acetyl)acetimide (6), and one new isoflavonoid glycoside, 6-O-methyl-7-O-Rrhamnopyranosyldaidzein (7), along with four known compounds. Their structures were elucidated by HRESIMS, 1H and 13C NMR, COSY, HMQC, HMBC, and NOESY spectra. Compounds 1-8 were evaluated for their inhibitory activities in the yeast glycogen synthase kinase-3� assay.

Dimensions Badge

Altmetric Badge

Item type Article
URI https://vuir.vu.edu.au/id/eprint/4220
DOI https://doi.org/10.1021/np900163f
Official URL http://dx.doi.org/10.1021/np900163f
Subjects Historical > Faculty/School/Research Centre/Department > School of Biomedical and Health Sciences
Current > FOR Classification > 1115 Pharmacology and Pharmaceutical Sciences
Keywords ResPubID19142. yeast glycogen synthase kinase-3β pathway inhibitors, organic extract of streptomyces sp., microbial fermentation organic extract, imides, glutarimide, propanimide, acetyl acetimide, isoflavonoid glycoside
Citations in Scopus 11 - View on Scopus
Download/View statistics View download statistics for this item

Search Google Scholar

Repository staff login