Flavonoids as an efective sensitizer for anti‑cancer therapy: insights into multi‑faceted mechanisms and applicability towards individualized patient profles

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Liskova, Alena, Samec, Marek, Koklesova, Lenka, Brockmueller, Aranka, Zhai, Kevin, Abdellatif, Basma, Siddiqui, Manaal, Biringer, Kamil, Kudela, Erik, Pec, Martin, Gadanec, Laura Kate ORCID: 0000-0002-4801-8061, Šudomová, Miroslava, Hassan, Sherif TS, Zulli, Anthony ORCID: 0000-0002-2660-078X, Shakibaei, Mehdi, Giordano, Frank A, Büsselberg, Dietrich, Golubnitschaja, Olga and Kubatka, Peter (2021) Flavonoids as an efective sensitizer for anti‑cancer therapy: insights into multi‑faceted mechanisms and applicability towards individualized patient profles. EPMA Journal, 12. pp. 155-176. ISSN 1878-5077

Abstract

Cost-efficacy of currently applied treatments is an issue in overall cancer management challenging healthcare and causing tremendous economic burden to societies around the world. Consequently, complex treatment models presenting concepts of predictive diagnostics followed by targeted prevention and treatments tailored to the personal patient profiles earn global appreciation as benefiting the patient, healthcare economy, and the society at large. In this context, application of flavonoids as a spectrum of compounds and their nano-technologically created derivatives is extensively under consideration, due to their multi-faceted anti-cancer effects applicable to the overall cost-effective cancer management, primary, secondary, and even tertiary prevention. This article analyzes most recently updated data focused on the potent capacity of flavonoids to promote anti-cancer therapeutic effects and interprets all the collected research achievements in the frame-work of predictive, preventive, and personalized (3P) medicine. Main pillars considered are: - Predictable anti-neoplastic, immune-modulating, drug-sensitizing effects; - Targeted molecular pathways to improve therapeutic outcomes by increasing sensitivity of cancer cells and reversing their resistance towards currently applied therapeutic modalities.

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Item type Article
URI https://vuir.vu.edu.au/id/eprint/44317
DOI https://doi.org/10.1007/s13167-021-00242-5
Official URL https://link.springer.com/article/10.1007/s13167-0...
Subjects Current > FOR (2020) Classification > 3208 Medical physiology
Current > Division/Research > Institute for Health and Sport
Keywords predictive preventive personalized medicine, 3PM/PPPM, phytochemicals, flavonoids, flavanones, flavonols, flavones, flavanols, isofavonoids, chalcones, anthocyanidins, anti-cancer agents, drug-sensitizing efect, targeted therapy, radiotherapy, chemotherapy, immunotherapy, therapy resistance, anti-infammation, antibacterial, anti-viral, COVID-19, signalling pathways, therapy efcacy, nano-carrier delivery, disease management, health economy, health policy
Citations in Scopus 35 - View on Scopus
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