Independent and Interactive Influences of Environmental UVR, Vitamin D Levels, and Folate Variant MTHFD1-rs2236225 on Homocysteine Levels

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Jones, Patrice ORCID: 0000-0002-4948-1445, Lucock, Mark, Martin, Charlotte, Thota, Rohith, Garg, Manohar, Yates, Zoe, Scarlett, Christopher J, Veysey, Martin and Beckett, Emma (2020) Independent and Interactive Influences of Environmental UVR, Vitamin D Levels, and Folate Variant MTHFD1-rs2236225 on Homocysteine Levels. Nutrients, 12 (5). ISSN 2072-6643

Abstract

Elevated homocysteine (Hcy) levels are a risk factor for vascular diseases. Recently, increases in ultraviolet radiation (UVR) have been linked to decreased Hcy levels. This relationship may be mediated by the status of UVR-responsive vitamins, vitamin D and folate, and/or genetic variants influencing their levels; however, this has yet to be examined. Therefore, the independent and interactive influences of environmental UVR, vitamin D and folate levels and related genetic variants on Hcy levels were examined in an elderly Australian cohort (n = 619). Red blood cell folate, 25-hydroxyvitamin D (25(OH)D), and plasma Hcy levels were determined, and genotyping for 21 folate and vitamin D-related variants was performed. Erythemal dose rate accumulated over six-weeks (6W-EDR) and four-months (4M-EDR) prior to clinics were calculated as a measure of environmental UVR. Multivariate analyses found interactions between 6W-EDR and 25(OH)D levels (pinteraction = 0.002), and 4M-EDR and MTHFD1-rs2236225 (pinteraction = 0.006) in predicting Hcy levels. The association between 6W-EDR and Hcy levels was found only in subjects within lower 25(OH)D quartiles (<33.26 ng/mL), with the association between 4M-EDR and Hcy occurring only in subjects carrying the MTHFD1-rs2236225 variant. 4M-EDR, 6W-EDR, and MTHFD1-rs2236225 were also independent predictors of Hcy. Findings highlight nutrient–environment and gene–environment interactions that could influence the risk of Hcy-related outcomes.

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Item type Article
URI https://vuir.vu.edu.au/id/eprint/44622
DOI https://doi.org/10.3390/nu12051455
Official URL http://dx.doi.org/10.3390/nu12051455
Subjects Current > FOR (2020) Classification > 3105 Genetics
Current > FOR (2020) Classification > 3210 Nutrition and dietetics
Current > Division/Research > Institute for Health and Sport
Keywords homocysteine, folate, vitamin D, ultraviolet radiation, genetic variant
Citations in Scopus 3 - View on Scopus
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