Vesiclepedia: a compendium for extracellular vesicles with continuous community annotation

Kalra, Hina, Simpson, Richard J, Ji, Hong, Aikawa, Elena, Altevogt, Peter, Askenase, Philip, Bond, Vincent C, Borràs, Francesc E, Breakefield, Xandra, Budnik, Vivian, Buzas, Edit, Camussi, Giovanni, Clayton, Aled ORCID: 0000-0002-3087-9226, Cocucci, Emanuele, Falcon-Perez, Juan Manuel, Gabrielsson, Susanne, Gho, Yong Song, Gupta, Dwijendra, Harsha, HC, Hendrix, An, Hill, Andrew F ORCID: 0000-0001-5581-2354, Inal, Jameel M, Jenster, Guido, Krämer-Albers, Eva-Maria, Lim, Sai Kiang, Llorente, Alicia, Lötvall, Jan, Marcilla, Antonio, Mincheva-Nilsson, Lucia, Nazarenko, Irina, Nieuwland, Rienk, Nolte-'t Hoen, Esther NM ORCID: 0000-0002-3172-9959, Pandey, Akhilesh, Patel, Tushar, Piper, Melissa G, Pluchino, Stefano ORCID: 0000-0002-6267-9472, Prasad, TS Keshava, Rajendran, Lawrence, Raposo, Graca, Record, Michel, Reid, Gavin E, Sánchez-Madrid, Francisco, Schiffelers, Raymond M, Siljander, Pia, Stensballe, Allan, Stoorvogel, Willem, Taylor, Douglas, Thery, Clotilde, Valadi, Hadi, van Balkom, Bas WM, Vázquez, Jesús, Vidal, Michel, Wauben, Marca HM, Yáñez-Mó, Maria, Zoeller, Margot and Mathivanan, Suresh ORCID: 0000-0002-7290-5795 (2012) Vesiclepedia: a compendium for extracellular vesicles with continuous community annotation. PLoS Biology, 10 (12). ISSN 1544-9173


Extracellular vesicles (EVs) are membraneous vesicles released by a variety of cells into their microenvironment. Recent studies have elucidated the role of EVs in intercellular communication, pathogenesis, drug, vaccine and gene-vector delivery, and as possible reservoirs of biomarkers. These findings have generated immense interest, along with an exponential increase in molecular data pertaining to EVs. Here, we describe Vesiclepedia, a manually curated compendium of molecular data (lipid, RNA, and protein) identified in different classes of EVs from more than 300 independent studies published over the past several years. Even though databases are indispensable resources for the scientific community, recent studies have shown that more than 50% of the databases are not regularly updated. In addition, more than 20% of the database links are inactive. To prevent such database and link decay, we have initiated a continuous community annotation project with the active involvement of EV researchers. The EV research community can set a gold standard in data sharing with Vesiclepedia, which could evolve as a primary resource for the field. © 2012 Kalra et al.

Dimensions Badge

Altmetric Badge

Item type Article
DOI 10.1371/journal.pbio.1001450
Official URL
Subjects Current > FOR (2020) Classification > 3101 Biochemistry and cell biology
Current > Division/Research > Chancellery
Keywords extracellular vesicles, EVs, intercellular communication
Citations in Scopus 898 - View on Scopus
Download/View statistics View download statistics for this item

Search Google Scholar

Repository staff login