Applying extracellular vesicles based therapeutics in clinical trials - An ISEV position paper

Lener, Thomas, Gimona, Mario, Aigner, Ludwig, Börger, Verena, Buzas, Edit, Camussi, Giovanni, Chaput, Nathalie, Chatterjee, Devasis, Court, Felipe A, del Portillo, Hernando A, O'Driscoll, Lorraine ORCID: 0000-0002-9860-8262, Fais, Stefano, Falcon-Perez, Juan Manuel, Felderhoff-Mueser, Ursula, Fraile, Lorenzo, Gho, Yong Song, Görgens, Andre, Gupta, Ramesh C, Hendrix, An, Hermann, Dirk M, Hill, Andrew F ORCID: 0000-0001-5581-2354, Hochberg, Fred, Horn, Peter A, de Kleijn, Dominique, Kordelas, Lambros, Kramer, Boris W, Krämer-Albers, Eva-Maria, Laner-Plamberger, Sandra, Laitinen, Saara, Leonardi, Tommaso ORCID: 0000-0002-4449-1863, Lorenowicz, Magdelena J, Lim, Sai Kiang, Lötvall, Jan, Maguire, Casey A, Marcilla, Antonio, Nazarenko, Irina, Ochiya, Takahiro, Patel, Tushar, Pedersen, Shona, Pocsfalvi, Gabriella, Pluchino, Stefano ORCID: 0000-0002-6267-9472, Quesenberry, Peter, Reischl, Ilona G, Rivera, Francisco J, Sanzenbacher, Ralf, Schallmoser, Katharina, Slaper-Cortenbach, Ineke, Strunk, Dirk, Tonn, Torsten, Vader, Pieter, van Balkom, Bas WM, Wauben, Marca HM, El Andaloussi, Samir El, Thery, Clotilde, Rohde, Eva and Giebel, Bernd (2015) Applying extracellular vesicles based therapeutics in clinical trials - An ISEV position paper. Journal of Extracellular Vesicles, 4 (1). ISSN 2001-3078


Extracellular vesicles (EVs), such as exosomes and microvesicles, are released by different cell types and participate in physiological and pathophysiological processes. EVs mediate intercellular communication as cell-derived extracellular signalling organelles that transmit specific information from their cell of origin to their target cells. As a result of these properties, EVs of defined cell types may serve as novel tools for various therapeutic approaches, including (a) anti-tumour therapy, (b) pathogen vaccination, (c) immune-modulatory and regenerative therapies and (d) drug delivery. The translation of EVs into clinical therapies requires the categorization of EV-based therapeutics in compliance with existing regulatory frameworks. As the classification defines subsequent requirements for manufacturing, quality control and clinical investigation, it is of major importance to define whether EVs are considered the active drug components or primarily serve as drug delivery vehicles. For an effective and particularly safe translation of EV-based therapies into clinical practice, a high level of cooperation between researchers, clinicians and competent authorities is essential. In this position statement, basic and clinical scientists, as members of the International Society for Extracellular Vesicles (ISEV) and of the European Cooperation in Science and Technology (COST) program of the European Union, namely European Network on Microvesicles and Exosomes in Health and Disease (ME-HaD), summarize recent developments and the current knowledge of EV-based therapies. Aspects of safety and regulatory requirements that must be considered for pharmaceutical manufacturing and clinical application are highlighted. Production and quality control processes are discussed. Strategies to promote the therapeutic application of EVs in future clinical studies are addressed.

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Item type Article
DOI 10.3402/jev.v4.30087
Official URL
Subjects Current > FOR (2020) Classification > 3207 Medical microbiology
Current > Division/Research > Chancellery
Keywords extracellular vesicles, EVs, intercellular communication, cells, clinical trials
Citations in Scopus 855 - View on Scopus
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