Neuroinflammation as an etiological trigger for depression comorbid with inflammatory bowel disease

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Craig, Colin F, Filippone, Rhiannon, Stavely, Rhian, Bornstein, Joel C, Apostolopoulos, Vasso ORCID: 0000-0001-6788-2771 and Nurgali, Kulmira ORCID: 0000-0002-2597-6929 (2022) Neuroinflammation as an etiological trigger for depression comorbid with inflammatory bowel disease. Journal of Neuroinflammation, 19. ISSN 1742-2094


Patients with inflammatory bowel disease (IBD) suffer from depression at higher rates than the general population. An etiological trigger of depressive symptoms is theorised to be inflammation within the central nervous system. It is believed that heightened intestinal inflammation and dysfunction of the enteric nervous system (ENS) contribute to impaired intestinal permeability, which facilitates the translocation of intestinal enterotoxins into the blood circulation. Consequently, these may compromise the immunological and physiological functioning of distant non-intestinal tissues such as the brain. In vivo models of colitis provide evidence of increased blood–brain barrier permeability and enhanced central nervous system (CNS) immune activity triggered by intestinal enterotoxins and blood-borne inflammatory mediators. Understanding the immunological, physiological, and structural changes associated with IBD and neuroinflammation may aid in the development of more tailored and suitable pharmaceutical treatment for IBD-associated depression.

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Item type Article
DOI 10.1186/s12974-021-02354-1
Official URL
Subjects Current > FOR (2020) Classification > 3204 Immunology
Current > FOR (2020) Classification > 3208 Medical physiology
Current > Division/Research > Institute for Health and Sport
Keywords infammatory bowel disease, depression, neuroinfammation, gut-brain axis
Citations in Scopus 13 - View on Scopus
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