Prion infection impairs cholesterol metabolism in neuronal cells

Cui, Huanhuan L, Guo, Belinda B, Scicluna, Benjamin J, Coleman, Bradley M, Lawson, Victoria A ORCID: 0000-0002-7362-7176, Ellett, Laura, Meikle, Peter ORCID: 0000-0002-2593-4665, Bukrinsky, Michael ORCID: 0000-0002-8593-0770, Mukhamedova, Nigora, Sviridov, Dmitri ORCID: 0000-0002-8366-3832 and Hill, Andrew F ORCID: 0000-0001-5581-2354 (2014) Prion infection impairs cholesterol metabolism in neuronal cells. Journal of Biological Chemistry, 289 (2). pp. 789-802. ISSN 0021-9258


Background: Cholesterol plays an important role in the pathogenesis of neurodegenerative diseases. Results: Prion infection increased abundance of cholesterol transporter ABCA1 but reduced its functionality. Stimulation of ABCA1 reduced the conversion of prion into the pathological form. Conclusion: ABCA1 plays a key role in pathogenesis of prion disease.

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Item type Article
DOI 10.1074/jbc.M113.535807
Official URL
Subjects Current > FOR (2020) Classification > 3101 Biochemistry and cell biology
Current > Division/Research > Chancellery
Keywords prion protein, PrP, cholesterol metabolism, lipids, neuronal cells
Citations in Scopus 30 - View on Scopus
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