Oxaliplatin-induced damage to the gastric innervation: role in nausea and vomiting

[thumbnail of biomolecules-13-00276-v2.pdf]
biomolecules-13-00276-v2.pdf - Published Version (5MB) | Preview
Available under license: Creative Commons Attribution

Rahman, Ahmed A ORCID: 0000-0003-4394-0118, Masango, Philenkosini, Stavely, Rhian, Bertrand, Paul ORCID: 0000-0003-1122-2306, Page, Amanda ORCID: 0000-0002-7086-5865 and Nurgali, Kulmira ORCID: 0000-0002-2597-6929 (2023) Oxaliplatin-induced damage to the gastric innervation: role in nausea and vomiting. Biomolecules, 13 (2). ISSN 2218-273X


Nausea and vomiting are common gastrointestinal side effects of oxaliplatin chemotherapy used for the treatment of colorectal cancer. However, the mechanism underlying oxaliplatin-induced nausea and vomiting is unknown. The stomach is involved in the emetic reflex but no study investigated the effects of oxaliplatin treatment on the stomach. In this study, the in vivo effects of oxaliplatin treatment on eating behaviour, stomach content, intrinsic gastric neuronal population, extrinsic innervation to the stomach, levels of mucosal serotonin (5-hydroxytryptamine, 5-HT), and parasympathetic vagal efferent nerve activity were analysed. Chronic systemic oxaliplatin treatment in mice resulted in pica, indicated by increased kaolin consumption and a reduction in body weight. Oxaliplatin treatment significantly increased the stomach weight and content. The total number of myenteric and nitric oxide synthase-immunoreactive neurons as well as the density of sympathetic, parasympathetic, and sensory fibres in the stomach were decreased significantly with oxaliplatin treatment. Oxaliplatin treatment significantly increased the levels in mucosal 5-HT and the number of enterochromaffin-like cells. Chronic oxaliplatin treatment also caused a significant increase in the vagal efferent nerve activity. The findings of this study indicate that oxaliplatin exposure has adverse effects on multiple components of gastric innervation, which could be responsible for pica and gastric dysmotility.

Dimensions Badge

Altmetric Badge

Item type Article
URI https://vuir.vu.edu.au/id/eprint/46942
DOI 10.3390/biom13020276
Official URL https://www.mdpi.com/2218-273X/13/2/276
Subjects Current > FOR (2020) Classification > 3202 Clinical sciences
Current > Division/Research > Australian Institute of Musculoskeletal Science (AIMSS)
Current > Division/Research > Institute for Health and Sport
Keywords nausea, vomiting, oxaliplatin chemotherapy, colorectal cancer treatment, stomach health
Download/View statistics View download statistics for this item

Search Google Scholar

Repository staff login