A study of the comparative effects of Hawthorn fruit compound and Simvastatin on lowering blood lipid levels

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Xu, Hong, Xu, Hou-En and Ryan, Damien (2009) A study of the comparative effects of Hawthorn fruit compound and Simvastatin on lowering blood lipid levels. American Journal of Chinese Medicine, 37 (5). pp. 903-908. ISSN 0192-415X


This project studied the lowering blood lipids effect in atherosclerotic ApoEdeficient mice. Group A mice (n = 6), fed with a normal diet, served as the negative control. The experimental groups used mice fed with a high cholesterol diet (HCD) for eight weeks, and then selected for inclusion in the study on the basis of high blood lipid levels and the formation of atherosclerotic lesion plaque, which was indicated by an ultrasound biomicroscopy test. Eighteen mice met the selection criteria (atherosclerotic mice with high blood lipid levels) and these were randomly assigned into three groups B, C and D (n = 6). Group B fed with a HCD, served as the positive control. The intervention Group C was fed with HCD and Simvastatin. The intervention Group D was fed with a HCD and Hawthorn fruit compound (HFC includes Hawthorn and Kiwi fruit extract) for eight weeks. The results showed that after feeding on a HCD, Group B had significantly higher blood lipid levels compared to Group A and this confirmed the validity of Group A and Group B controls in this study. The results also showed that compared to Group B, in both Group C and D, there was a significant reduction in triglyceride and in the ratio between low-density lipoprotein cholesterol (LDL-C) and serum cholesterol. Moreover a reduction of LDL-C was evident in Group D, whereas a similar effect did not occur in Group C. The results indicate that HFC can be considered for the treatment of hyperlipidemia and prevention of atherosclerosis.

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Item type Article
URI https://vuir.vu.edu.au/id/eprint/4708
DOI 10.1142/S0192415X09007302
Subjects Historical > Faculty/School/Research Centre/Department > School of Biomedical and Health Sciences
Historical > FOR Classification > 1104 Complementary and Alternative Medicine
Historical > SEO Classification > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions)
Keywords ResPubID17439, blood lipid, hawthorn fruit (shan zha), Chinese kiwi fruit, Simvastatin and ApoE-deficient mice
Citations in Scopus 21 - View on Scopus
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