The Oxidative Stress and Nervous Distress Connection in Gastrointestinal Disorders

[thumbnail of biomolecules-13-01586.pdf]
biomolecules-13-01586.pdf - Published Version (1MB) | Preview
Available under license: Creative Commons Attribution

Stavely, Rhian ORCID: 0000-0002-5099-3704, Ott, Leah C ORCID: 0000-0003-3889-1550, Rashidi, Niloufar, Sakkal, Samy ORCID: 0000-0003-0430-4012 and Nurgali, Kulmira ORCID: 0000-0002-2597-6929 (2023) The Oxidative Stress and Nervous Distress Connection in Gastrointestinal Disorders. Biomolecules, 13 (11). ISSN 2218-273X


Oxidative stress is increasingly recognized as a central player in a range of gastrointestinal (GI) disorders, as well as complications stemming from therapeutic interventions. This article presents an overview of the mechanisms of oxidative stress in GI conditions and highlights a link between oxidative insult and disruption to the enteric nervous system (ENS), which controls GI functions. The dysfunction of the ENS is characteristic of a spectrum of disorders, including neurointestinal diseases and conditions such as inflammatory bowel disease (IBD), diabetic gastroparesis, and chemotherapy-induced GI side effects. Neurons in the ENS, while essential for normal gut function, appear particularly vulnerable to oxidative damage. Mechanistically, oxidative stress in enteric neurons can result from intrinsic nitrosative injury, mitochondrial dysfunction, or inflammation-related pathways. Although antioxidant-based therapies have shown limited efficacy, recognizing the multifaceted role of oxidative stress in GI diseases offers a promising avenue for future interventions. This comprehensive review summarizes the literature to date implicating oxidative stress as a critical player in the pathophysiology of GI disorders, with a focus on its role in ENS injury and dysfunction, and highlights opportunities for the development of targeted therapeutics for these diseases.

Dimensions Badge

Altmetric Badge

Item type Article
DOI 10.3390/biom13111586
Official URL
Subjects Current > FOR (2020) Classification > 3202 Clinical sciences
Current > FOR (2020) Classification > 3205 Medical biochemistry and metabolomics
Current > FOR (2020) Classification > 3208 Medical physiology
Current > Division/Research > Institute for Health and Sport
Keywords oxidative stress; reactive oxygen species; gastrointestinal; enteric nervous system; enteric neuron; neurointestinal
Download/View statistics View download statistics for this item

Search Google Scholar

Repository staff login