Development of allergic responses related to microorganisms exposure in early life

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Vasiljevic, Todor ORCID: 0000-0003-1395-7349, Shah, Nagendra P, Donkor, Osaana ORCID: 0000-0001-9565-9024 and Apostolopoulos, Vasso ORCID: 0000-0001-6788-2771 (2010) Development of allergic responses related to microorganisms exposure in early life. International Dairy Journal, 20 (6). pp. 373-385. ISSN 0958-6946


The prevalence of allergic disorders may stem from reduced microbial exposure during childhood. Allergic disorders (rhinitis, asthma, atopic dermatitis) result from a systemic inflammatory reaction triggered by Th2-cell-mediated immune responses against ‘innocuous’ environmental antigens. Initial interpretations proposed an immune deviation of allergen-specific responses from a Th1 to a Th2 profile resulting from reduced production of interleukin-12 and interferons by natural immune cells stimulated by bacterial products. Both stereotypical and selective responses of innate host cells are invoked by different microorganisms. Early in an infection, pathogens can therefore imprint their ‘signatures’ on antigen-presenting cells and subsequent immune responses. This interaction between microorganisms and enterocytes is important for the controlled production of cytokines and chemokines. Some probiotic microorganisms can modulate the in vitro expression of pro- and anti-inflammatory cytokines in a straindependent manner, probably skew the immune response towards Th1 phenotype and play an important role in allergy prevention.

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Item type Article
DOI 10.1016/j.idairyj.2009.12.017
Official URL
Subjects Historical > Faculty/School/Research Centre/Department > School of Biomedical and Health Sciences
Historical > FOR Classification > 0908 Food Sciences
Historical > SEO Classification > 8602 Dairy Products
Keywords ResPubID19751, allergic disorders, reduced microbial exposure in childhood, rhinitis, asthma, atopic dermatitis, Th2-cell-mediated immune responses, reduced production of interleukin-12, pathogen ‘signatures’, immune responses
Citations in Scopus 10 - View on Scopus
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