The applied biochemistry of PEDF and implications for tissue homeostasis

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Broadhead, Matthew L, Becerra, S. Patricia, Choong, Peter F. M and Dass, Crispin R (2010) The applied biochemistry of PEDF and implications for tissue homeostasis. Growth Factors, 28 (4). pp. 280-285. ISSN 0897-7194

Abstract

Pigment epithelium-derived factor (PEDF) is an endogenously produced glycoprotein with a spectrum of biological roles across diverse pathologies. Recent research has focused on the biochemical properties of PEDF and its associated receptors. This review discusses the recent developments in PEDF biochemistry and how this new knowledge will help progress our understanding of PEDF as a molecular mediator for anti-angiogenesis and -tumorigenesis. Additionally, pathophysiological roles for PEDF in healing and tissue homeostasis are being revealed and our enhanced understanding of the interactions between PEDF and its receptors may yet prove useful in propelling PEDF towards clinical application.

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Item type Article
URI https://vuir.vu.edu.au/id/eprint/7562
DOI https://doi.org/10.3109/08977191003604513
Subjects Historical > Faculty/School/Research Centre/Department > School of Biomedical and Health Sciences
Historical > FOR Classification > 1101 Medical Biochemistry and Metabolomics
Historical > FOR Classification > 1103 Clinical Sciences
Historical > FOR Classification > 1112 Oncology and Carcinogenesis
Historical > FOR Classification > 1116 Medical Physiology
Historical > SEO Classification > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions)
Keywords ResPubID21857. pigment epithelium derived factor, structure, receptor, biochemistry, healing, repair, PEDF, anti-angiogenic, angiogenesis inhibitors, eye growth, eye proteins, antineoplastic, serpins, anti-tumorigenesis, cancer
Citations in Scopus 22 - View on Scopus
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