Microarray: an instrument for cancer surgeons of the future? : Surgical science

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Broadhead, Matthew L, Clark, Jonathan C. M, Dass, Crispin R and Choong, Peter F. M (2010) Microarray: an instrument for cancer surgeons of the future? : Surgical science. ANZ Journal of Surgery, 80 (7-8). pp. 531-536. ISSN 1445-1433


Microarray enables the study of thousands of genes simultaneously. While still in its infancy as a technique and with a number of barriers to be overcome, microarray is allowing scientists to thoroughly examine the molecular pathways of cancer pathogenesis. However, the adoption of microarray as a clinically applicable technique has been slow coming. Current literature suggests roles in the diagnosis of tumours of unknown origin, in the evaluation of prognostic markers, and in guiding treatment for recurrent and resistant malignancy. This review outlines the science of microarray and draws on clinical examples, including osteosarcoma, breast, prostate and pancreatic carcinomas, to highlight the potential of microarray as a technique of surgical importance.

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Online ISSN: 1445-2197

Item type Article
URI https://vuir.vu.edu.au/id/eprint/7563
DOI 10.1111/j.1445-2197.2010.05379.x
Official URL http://dx.doi.org/10.1111/j.1445-2197.2010.05379.x
Subjects Historical > Faculty/School/Research Centre/Department > School of Biomedical and Health Sciences
Historical > FOR Classification > 1101 Medical Biochemistry and Metabolomics
Historical > FOR Classification > 1103 Clinical Sciences
Historical > FOR Classification > 1112 Oncology and Carcinogenesis
Historical > SEO Classification > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions)
Keywords ResPubID21858. microarray, osteosarcoma, bone cancer, breast cancer, prostate cancer, pancreas cancer, tumours, cancer pathogenesis, cancer therapy, genetic profiles, prognostic markers, chemoresistance, prognosis
Citations in Scopus 10 - View on Scopus
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