Cancer cell apoptotic pathways mediated by PEDF: prospects for therapy

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Broadhead, Matthew L, Dass, Crispin R and Choong, Peter F. M (2009) Cancer cell apoptotic pathways mediated by PEDF: prospects for therapy. Trends in Molecular Medicine, 15 (10). pp. 461-467. ISSN 1471-4914


Pigment epithelium-derived factor (PEDF) has roles in antiangiogenesis and antitumourigenesis that are intimately entwined and is showing promise as a potential anticancer agent. However, the function of PEDF in the deregulated apoptotic pathways of malignant cells must first be fully characterized. Here, we review the currently known apoptotic pathways that are relevant to PEDF and cancer. Recently, a pathway that includes the PEDF receptor, PPARg and p53 has emerged. It is hoped that further characterization of this and other pathways involved in cancer will bring to light potential new therapeutic targets and approaches, which due to their specificity might be free of the morbidity associated with conventional chemotherapy.

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Item type Article
DOI 10.1016/j.molmed.2009.08.003
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Subjects Historical > Faculty/School/Research Centre/Department > School of Biomedical and Health Sciences
Historical > FOR Classification > 1112 Oncology and Carcinogenesis
Historical > SEO Classification > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions)
Keywords ResPubID21876. cancer cell apoptotic pathways, PEDF, cancer therapy, pigment epithelium-derived factor, anticancer agents, malignant, cancer cells,
Citations in Scopus 36 - View on Scopus
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