A chitosan hydrogel delivery system for osteosarcoma gene therapy with pigment epithelium-derived factor combined with chemotherapy

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Ta, Hang T, Dass, Crispin R, Larson, Ian, Choong, Peter F. M and Dunstan, David E (2009) A chitosan hydrogel delivery system for osteosarcoma gene therapy with pigment epithelium-derived factor combined with chemotherapy. Biomaterials, 30 (27). pp. 4815-4823. ISSN 0142-9612

Abstract

Osteosarcoma (OS) is the most common type of malignant bone cancer, and the sixth most common type of cancer in children and young adults. Currently, gene therapy is being evaluated as a novel method for OS treatment. Here we report on an in situ gelling chitosan-based hydrogel system that sustains the release of a potential anti-cancer gene (pigment epithelium-derived factor) to the tumor site. A significant reduction of the primary OS in a clinically relevant orthotopic model was measured. The combination of plasmid treatment and chemotherapy together with the use of this delivery system led to the highest suppression of tumor growth without side effects. The results obtained from this study demonstrate the potential application of a biodegradable hydrogel technology as an anti-cancer drug delivery system for successful chemo-gene therapy.

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Item type Article
URI https://vuir.vu.edu.au/id/eprint/7581
DOI https://doi.org/10.1016/j.biomaterials.2009.05.035
Official URL http://dx.doi.org/10.1016/j.biomaterials.2009.05.0...
Subjects Historical > Faculty/School/Research Centre/Department > School of Biomedical and Health Sciences
Historical > FOR Classification > 1112 Oncology and Carcinogenesis
Historical > SEO Classification > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions)
Keywords ResPubID21877. chitosan, orthophosphate, drug delivery, hydrogel, osteosarcoma, bone cancer, gene therapy, cancer therapy, pigment epithelium-derived factor, tumours, chemotherapy
Citations in Scopus 83 - View on Scopus
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