Osteosarcoma treatment: state of the art

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Ta, Hang T, Dass, Crispin R, Choong, Peter F. M and Dunstan, David E (2009) Osteosarcoma treatment: state of the art. Cancer and Metastasis Reviews, 28 (1-2). pp. 247-263. ISSN 0167-7659

Abstract

Osteosarcoma (OS) is a class of cancer originating from bone, mainly afflicting children or young adults. It is the second highest cause of cancer-related death in these age groups, mainly due to development of often fatal metastasis, usually in the lungs. Survival for these patients is poor despite the aggressive use of surgery, chemotherapy, and/or radiotherapy. Thus, new effective drugs and other forms of therapy are needed. This article reviews the biology and the state of the art management of OS. New experimental drugs and potential therapies targeting molecular pathways of OS are also discussed.

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Item type Article
URI https://vuir.vu.edu.au/id/eprint/7584
DOI https://doi.org/10.1007/s10555-009-9186-7
Official URL http://dx.doi.org/10.1007/s10555-009-9186-7
Subjects Historical > Faculty/School/Research Centre/Department > School of Biomedical and Health Sciences
Historical > FOR Classification > 1112 Oncology and Carcinogenesis
Historical > SEO Classification > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions)
Keywords ResPubID21881. osteosarcoma, tumours, bone cancer, chemotherapy, radiotherapy, cancer therapy lung metastasis
Citations in Scopus 251 - View on Scopus
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