Osteosarcoma: conventional treatment vs. gene therapy

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Tan, M, Choong, Peter F. M and Dass, Crispin R (2009) Osteosarcoma: conventional treatment vs. gene therapy. Cancer Biology and Therapy, 8 (2). pp. 106-117. ISSN 1538-4047


Osteosarcoma (OS) remains the most common primary malignant bone cancer affecting children and adolescents. A majority of patients are subjected to surgery and chemotherapy with limited alternatives to consider. However, with increasing knowledge of the molecular pathogenesis of OS, advancements in the OS therapy research field have developed potential agents for a more targeted and localised approach to treatment. Thus, this review attempts to examine some common treatment strategies (surgery, radiotherapy and chemotherapy) employed clinically as well as recent developments in newer experimental therapy methods (gene therapy) which might benefit patients.

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Item type Article
URI https://vuir.vu.edu.au/id/eprint/7587
DOI 10.4161/cbt.8.2.7385
Official URL http://dx.doi.org/10.4161/cbt.8.2.7385
Subjects Historical > Faculty/School/Research Centre/Department > School of Biomedical and Health Sciences
Historical > FOR Classification > 1112 Oncology and Carcinogenesis
Historical > SEO Classification > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions)
Keywords ResPubID21884. osteosarcoma, bone cancer, cancer therapy, gene therapy, chemotherapy, radiotherapy, surgery, conventional medicine, experimental therapies
Citations in Scopus 93 - View on Scopus
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