c-Jun is critical for the progression of osteosarcoma: proof in an orthotopic spontaneously metastasizing model.

Full text for this resource is not available from the Research Repository.

Dass, Crispin R, Khachigian, Levon M and Choong, Peter F. M (2008) c-Jun is critical for the progression of osteosarcoma: proof in an orthotopic spontaneously metastasizing model. Molecular Cancer Research, 6 (8). pp. 1289-1292. ISSN 1541-7786

Abstract

The oncogene c-Jun has been found to be up-regulated in a variety of cancers including osteosarcoma. DNA enzymes (DNAzymes) are oligonucleotides capable of specific catalysis of target mRNA. A c-Jun DNAzyme inhibited the growth and metastasis of osteosarcoma in an orthotopic spontaneously metastasizing model of the disease. c-Jun down-regulation–mediated apoptosis in osteosarcoma cells involved caspase-1, caspase-2, and caspase-8, but not the Fas/FasL pathway. Clinically, knockdown of c-Jun with DNAzymes may proffer an improved treatment outcome for these tumors originating in bone. A correction to this article has also been published.

Dimensions Badge

Altmetric Badge

Item type Article
URI https://vuir.vu.edu.au/id/eprint/7592
DOI https://doi.org/10.1158/1541-7786.MCR-08-0036
Official URL http://dx.doi.org/10.1158/1541-7786.MCR-08-0036
Subjects Historical > Faculty/School/Research Centre/Department > School of Biomedical and Health Sciences
Historical > FOR Classification > 1112 Oncology and Carcinogenesis
Historical > SEO Classification > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions)
Keywords ResPubID21889, ResPubID18867, c-Jun, cancer, apoptosis, deoxyribozyme, oncogene, bone, osteosarcoma, orthotopic, spontaneously metastasizing model, metastasis, DNAzyme
Citations in Scopus 28 - View on Scopus
Download/View statistics View download statistics for this item

Search Google Scholar

Repository staff login