Impact of the neuroendocrine system on thymus and bone marrow function

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Barnard, Adele, Layton, Daniel, Hince, Melanie, Sakkal, Samy, Bernard, Claude A, Chidgey, Ann P and Boyd, Richard L (2008) Impact of the neuroendocrine system on thymus and bone marrow function. Neuroimmunomodulation, 15 (1). pp. 7-18. ISSN 1021-7401


The nervous, endocrine, and immune systems interact to adapt to infection, inflammation, and tissue injury. Neural control is mediated in several ways, one of them being through the neuroendocrine regulation of the secretion of hypothalamic and pituitary hormones. The hormonal effects on the immune system range from the impact of steroidal hormones, which exhibit inhibitory effects over immune functions, to growth hormone, prolactin and neurohypophyseal hormones, known to stimulate and modulate humoral and cellular aspects of the immune system. This review will discuss the mechanisms behind the immunomodulatory role of the neuroendocrine system, including the critically important feedback loops required to maintain balance for these bidirectional interactions and alterations that occur with age.

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Additional Information

Online ISSN: 1423-0216

Item type Article
DOI 10.1159/000135619
Subjects Historical > Faculty/School/Research Centre/Department > School of Biomedical and Health Sciences
Historical > FOR Classification > 1103 Clinical Sciences
Keywords ResPubID22583. neuroendocrine system, endocrine system, nervous system, thymus, bone marrow, immune system, thymus, testosterone, estrogen, prolactin, progesterone, growth hormones, glucocorticoid, neurosecretory systems
Citations in Scopus 23 - View on Scopus
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