Turning down lipid oxidation during heavy exercise - What is the mechanism?

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Sahlin, Kent, Sallstedt, E, Bishop, David ORCID: 0000-0002-6956-9188 and Tonkonogi, Michail (2008) Turning down lipid oxidation during heavy exercise - What is the mechanism? Journal of Physiology and Pharmacology, 59 (Supp.7). pp. 19-30. ISSN 0867-5910 (print) 1899-1505 (online)


A high potential for lipid oxidation is a sign of metabolic fitness and is important not only for exercise performance but also for health promotion. Despite considerable progress during recent years, our understanding of how lipid oxidation is controlled remains unclear. The rate of lipid oxidation reaches a peak at 50-60% of v·O2 max after which the contribution of lipids decreases both in relative and absolute terms. In the high-intensity domain (>60% v·O2 max), there is a pronounced decrease in energy state, which will stimulate the glycolytic rate in excess of the substrate requirements of mitochondrial oxidative processes. Accumulation of glycolytic products will impair lipid oxidation through an interaction with the carnitine-mediated transfer of FA into mitochondria. Another potential site of control is Acyl-CoA synthetase (ACS), which is the initial step in FA catabolism. The activity of ACS may be under control of CoASH and energy state. There is evidence that additional control points exist beyond mitochondrial influx of fatty acids. The electron transport chain (ETC) with associated feed-back control by redox state is one suggested candidate. In this review it is suggested that the control of FA oxidation during heavy exercise is distributed between ACS, CPT1, and ETC.

Additional Information

Online ISSN: 1899-1505

Item type Article
URI https://vuir.vu.edu.au/id/eprint/7987
Official URL http://www.jpp.krakow.pl/
Subjects Historical > FOR Classification > 1101 Medical Biochemistry and Metabolomics
Historical > FOR Classification > 1106 Human Movement and Sports Science
Historical > Faculty/School/Research Centre/Department > Institute of Sport, Exercise and Active Living (ISEAL)
Keywords ResPubID22024. carbohydrate oxidation, intense excercise, lipiel oxidation, mitochondria, metabolic regulation
Citations in Scopus 43 - View on Scopus
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