Leptin resistance and obesity

Full text for this resource is not available from the Research Repository.

Enriori, Pablo J, Evans, Anne E, Sinnayah, Puspha and Cowley, Michael A (2006) Leptin resistance and obesity. Obesity, 14 (Suppl.). 254S-258S. ISSN 1930-7381

Abstract

The prevalence of obesity, and the human and economic costs of the disease, creates a need for better therapeutics and better understanding of the physiological processes that balance energy intake and energy expenditure. Leptin is the primary signal from energy stores and exerts negative feedback effects on energy intake. In common obesity, leptin loses the ability to inhibit energy intake and increase energy expenditure; this is termed leptin resistance. This review discusses the evidence in support of leptin resistance in mouse models and humans and the possible mechanisms of leptin resistance.

Dimensions Badge

Altmetric Badge

Item type Article
URI https://vuir.vu.edu.au/id/eprint/8074
DOI https://doi.org/10.1038/oby.2006.319
Official URL http://dx.doi.org/10.1038/oby.2006.319
Subjects Historical > Faculty/School/Research Centre/Department > School of Biomedical and Health Sciences
Historical > FOR Classification > 1101 Medical Biochemistry and Metabolomics
Keywords ResPubID22120. leptin resistance, obesity, proopiomelanocortin, agouti-related peptide, arcuate nucleus, suppressor of cytokine signaling-3, food intake
Citations in Scopus 214 - View on Scopus
Download/View statistics View download statistics for this item

Search Google Scholar

Repository staff login