Leptin resistance and obesity

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Enriori, Pablo J, Evans, Anne E, Sinnayah, Puspha and Cowley, Michael A (2006) Leptin resistance and obesity. Obesity, 14 (Suppl.). 254S-258S. ISSN 1930-7381


The prevalence of obesity, and the human and economic costs of the disease, creates a need for better therapeutics and better understanding of the physiological processes that balance energy intake and energy expenditure. Leptin is the primary signal from energy stores and exerts negative feedback effects on energy intake. In common obesity, leptin loses the ability to inhibit energy intake and increase energy expenditure; this is termed leptin resistance. This review discusses the evidence in support of leptin resistance in mouse models and humans and the possible mechanisms of leptin resistance.

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Item type Article
URI https://vuir.vu.edu.au/id/eprint/8074
DOI 10.1038/oby.2006.319
Official URL http://dx.doi.org/10.1038/oby.2006.319
Subjects Historical > Faculty/School/Research Centre/Department > School of Biomedical and Health Sciences
Historical > FOR Classification > 1101 Medical Biochemistry and Metabolomics
Keywords ResPubID22120. leptin resistance, obesity, proopiomelanocortin, agouti-related peptide, arcuate nucleus, suppressor of cytokine signaling-3, food intake
Citations in Scopus 226 - View on Scopus
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