Hypothalamic regulatory pathways and potential obesity treatment targets

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Jobst, Erin E, Enriori, Pablo J, Sinnayah, Puspha and Cowley, Michael A (2006) Hypothalamic regulatory pathways and potential obesity treatment targets. Endocrine, 29 (1). pp. 33-48. ISSN 0969-711X

Abstract

With an ever-growing population of obese people as well as comorbidities associated with obesity, finding effective weight loss strategies is more imperative than ever. One of the challenges in curbing the obesity crisis is designing successful strategies for long-term weight loss and weight-loss maintenance. Currently, weight-loss strategies include promotion of therapeutic lifestyle changes (diet and exercise), pharmacological therapy, and bariatric surgery. This review focuses on several pharmacological targets that activate central nervous system pathways that normally limit food intake and body weight. Though it is likely that no single therapy will prove effective for everyone, this review considers several recent pre-clinical targets, and several compounds that have been in human clinical trials.

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Additional Information	Online ISSN: 1559-0100
Item type	Article
URI	https://vuir.vu.edu.au/id/eprint/8083
DOI	10.1385/ENDO:29:1:33
Subjects	Historical > Faculty/School/Research Centre/Department > School of Biomedical and Health Sciences Historical > FOR Classification > 1101 Medical Biochemistry and Metabolomics Historical > FOR Classification > 1115 Pharmacology and Pharmaceutical Sciences
Keywords	ResPubID22129. obesity, weight-loss, hypothalamus, drug targets, melanocortin, NPY, MCH, cannabinoid, CART, CNTF, AMP kinase, topiramate
Citations in Scopus	8 - View on Scopus
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