Hypothalamic regulatory pathways and potential obesity treatment targets

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Jobst, Erin E, Enriori, Pablo J, Sinnayah, Puspha and Cowley, Michael A (2006) Hypothalamic regulatory pathways and potential obesity treatment targets. Endocrine, 29 (1). pp. 33-48. ISSN 0969-711X


With an ever-growing population of obese people as well as comorbidities associated with obesity, finding effective weight loss strategies is more imperative than ever. One of the challenges in curbing the obesity crisis is designing successful strategies for long-term weight loss and weight-loss maintenance. Currently, weight-loss strategies include promotion of therapeutic lifestyle changes (diet and exercise), pharmacological therapy, and bariatric surgery. This review focuses on several pharmacological targets that activate central nervous system pathways that normally limit food intake and body weight. Though it is likely that no single therapy will prove effective for everyone, this review considers several recent pre-clinical targets, and several compounds that have been in human clinical trials.

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Additional Information

Online ISSN: 1559-0100

Item type Article
URI https://vuir.vu.edu.au/id/eprint/8083
DOI 10.1385/ENDO:29:1:33
Subjects Historical > Faculty/School/Research Centre/Department > School of Biomedical and Health Sciences
Historical > FOR Classification > 1101 Medical Biochemistry and Metabolomics
Historical > FOR Classification > 1115 Pharmacology and Pharmaceutical Sciences
Keywords ResPubID22129. obesity, weight-loss, hypothalamus, drug targets, melanocortin, NPY, MCH, cannabinoid, CART, CNTF, AMP kinase, topiramate
Citations in Scopus 8 - View on Scopus
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