L-Arginine infusion increases glucose clearance during prolonged exercise in humans

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McConell, Glenn ORCID: 0000-0002-8572-9065, Huynh, N. N, Lee-Young, Robert S, Canny, Benedict J and Wadley, Glenn D (2006) L-Arginine infusion increases glucose clearance during prolonged exercise in humans. American Journal of Physiology - Endocrinology and Metabolism, 290 (1). E60-E66. ISSN 0193-1849


Nitric oxide synthase (NOS) inhibition has been shown in humans to attenuate exercise-induced increases in muscle glucose uptake. We examined the effect of infusing the NO precursor L-arginine (L-Arg) on glucose kinetics during exercise in humans. Nine endurance-trained males cycled for 120 min at 72 ± 1% O2 peak followed immediately by a 15-min "all-out" cycling performance bout. A [6,6-2H]glucose tracer was infused throughout exercise, and either saline alone (Control, CON) or saline containing L-Arg HCl (L-Arg, 30 g at 0.5 g/min) was coinfused in a double-blind, randomized order during the last 60 min of exercise. L-Arg augmented the increases in glucose rate of appearance, glucose rate of disappearance, and glucose clearance rate (L-Arg: 16.1 ± 1.8 ml·min–1·kg–1; CON: 11.9 ± 0.7 ml·min–1·kg–1 at 120 min, P < 0.05) during exercise, with a net effect of reducing plasma glucose concentration during exercise. L-Arg infusion had no significant effect on plasma insulin concentration but attenuated the increase in nonesterified fatty acid and glycerol concentrations during exercise. L-Arg infusion had no effect on cycling exercise performance. In conclusion, L-Arg infusion during exercise significantly increases skeletal muscle glucose clearance in humans. Because plasma insulin concentration was unaffected by L-Arg infusion, greater NO production may have been responsible for this effect.

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Online ISSN: 1522-1555

Item type Article
URI https://vuir.vu.edu.au/id/eprint/8095
DOI 10.​1152/​ajpendo.​00263.​2005
Official URL http://dx.doi.org/10.1152/ajpendo.00263.2005
Subjects Historical > FOR Classification > 1101 Medical Biochemistry and Metabolomics
Historical > FOR Classification > 1106 Human Movement and Sports Science
Historical > Faculty/School/Research Centre/Department > Institute of Sport, Exercise and Active Living (ISEAL)
Keywords ResPubID22143. nitric oxide synthase, NOS, glucose kinetics, contraction, L-Arginine infusion, prolonged exercise, cycling, skeletal muscle, plasma
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