The Malarial Drug Target Plasmodium falciparum 1-Deoxy-D-Xylulose-5- Phosphate Reductoisomerase (PfDXR): Development of a 3-D Model for Identification of Novel, Structural and Functional Features and for Inhibitor Screening
Download
Download
Download
Full text for this resource is not available from the Research Repository.
Export
Goble, Jessica L, Adendorff, Matthew R, de Beer, Tjaart A. P, Stephens, Linda L and Blatch, Gregory 
ORCID: 0000-0003-0778-8577
(2010)
The Malarial Drug Target Plasmodium falciparum 1-Deoxy-D-Xylulose-5- Phosphate Reductoisomerase (PfDXR): Development of a 3-D Model for Identification of Novel, Structural and Functional Features and for Inhibitor Screening.
Protein and Peptide Letters, 17 (1).
pp. 109-120.
ISSN 0929-8665 (print) 1875-5305 (online)
Abstract
A three-dimensional model of the malarial drug target protein PfDXR was generated, and validated using structure-checking programs and protein docking studies. Structural and functional features unique to PfDXR were identified using the model and comparative sequence analyses with apicomplexan and non-apicomplexan DXR proteins. Furthermore, we have used the model to develop an efficient approach to screen for potential tool compounds for use in the rational design of novel DXR inhibitors.
| Item type | Article |
| URI | https://vuir.vu.edu.au/id/eprint/8134 |
| Official URL | http://www.benthamdirect.org/pages/content.php?PPL... |
| Subjects | Historical > Faculty/School/Research Centre/Department > School of Biomedical and Health Sciences Historical > FOR Classification > 1101 Medical Biochemistry and Metabolomics |
| Keywords | ResPubID22188, PfDXR, antimalarial, apicomplexan, inhibitors, fosmidomycin, binding affinity, IC50 |
| Citations in Scopus | 12 - View on Scopus |
| Download/View statistics | View download statistics for this item |
CORE (COnnecting REpositories)