3-Substituted Anilines as Scaffolds for the Construction of Glutamine Synthetase and DXP-Reductoisomerase Inhibitors

Download

Full text for this resource is not available from the Research Repository.

Export

Mutorwa, Marius, Salisu, Sheriff, Blatch, Gregory ORCID: 0000-0003-0778-8577, Kenyon, Colin and Kaye, Perry T (2009) 3-Substituted Anilines as Scaffolds for the Construction of Glutamine Synthetase and DXP-Reductoisomerase Inhibitors. Synthetic Communications: An International Journal for Rapid Communication of Synthetic Organic Chemistry , 39 (15). pp. 2723-2736. ISSN 0039-7911

Abstract

Access to a series of truncated ATP analogs, as potential anti-tuberculosis agents, has been explored via alkylation and acylation of 3-aminophenol, whereas chloroacetylation, using chloroacetyl chloride, and subsequent Arbuzov phosphonation of a series of 3-substituted anilines have afforded a series of phosphonate derivatives as potential antimalarial agents.

Dimensions Badge

Altmetric Badge

Item type	Article
URI	https://vuir.vu.edu.au/id/eprint/8138
DOI	10.1080/00397910802663444
Subjects	Historical > Faculty/School/Research Centre/Department > School of Biomedical and Health Sciences Historical > FOR Classification > 1101 Medical Biochemistry and Metabolomics
Keywords	ResPubID22192, aniline derivatives, DXP-reductoisomerase inhibitors, glutamine synthetase, phosphonates
Citations in Scopus	7 - View on Scopus
Download/View statistics	View download statistics for this item