3-Substituted Anilines as Scaffolds for the Construction of Glutamine Synthetase and DXP-Reductoisomerase Inhibitors

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Mutorwa, Marius, Salisu, Sheriff, Blatch, Gregory L, Kenyon, Colin and Kaye, Perry T (2009) 3-Substituted Anilines as Scaffolds for the Construction of Glutamine Synthetase and DXP-Reductoisomerase Inhibitors. Synthetic Communications: An International Journal for Rapid Communication of Synthetic Organic Chemistry , 39 (15). pp. 2723-2736. ISSN 0039-7911

Abstract

Access to a series of truncated ATP analogs, as potential anti-tuberculosis agents, has been explored via alkylation and acylation of 3-aminophenol, whereas chloroacetylation, using chloroacetyl chloride, and subsequent Arbuzov phosphonation of a series of 3-substituted anilines have afforded a series of phosphonate derivatives as potential antimalarial agents.

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Item type Article
URI https://vuir.vu.edu.au/id/eprint/8138
DOI https://doi.org/10.1080/00397910802663444
Subjects Historical > Faculty/School/Research Centre/Department > School of Biomedical and Health Sciences
Historical > FOR Classification > 1101 Medical Biochemistry and Metabolomics
Keywords ResPubID22192, aniline derivatives, DXP-reductoisomerase inhibitors, glutamine synthetase, phosphonates
Citations in Scopus 7 - View on Scopus
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