The TPR2B domain of the hsp70/Hsp90 organizing protein (Hop) may contribute towards its dimerization
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Longshaw, Victoria M, Stephens, Linda L, Daniel, Sheryl and Blatch, Gregory 
ORCID: 0000-0003-0778-8577
(2009)
The TPR2B domain of the hsp70/Hsp90 organizing protein (Hop) may contribute towards its dimerization.
Protein and Peptide Letters, 16 (4).
pp. 402-407.
ISSN 0929-8665 (print) 1875-5305 (online)
Abstract
The role of the TPR2B domain of Hop is as yet unknown. We have shown here by site directed mutagenesis and size exclusion chromatography for the first time that the TPR1 and TPR2B domains of Hop independently dimerized, and that the dimerization of TPR2B was not dependent on its predicted two-carboxylate clamp residues. Furthermore, our data indicated that the dimerization of Hop and its domains was not disrupted in the presence of Hsp70 and Hsp90 peptides.
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| Item type | Article |
| URI | https://vuir.vu.edu.au/id/eprint/8142 |
| DOI | 10.2174/092986609787848162 |
| Subjects | Historical > Faculty/School/Research Centre/Department > School of Biomedical and Health Sciences Historical > FOR Classification > 0601 Biochemistry and Cell Biology |
| Keywords | ResPubID22196. multimerization, heat shock proteins, amino acids, molecular wequence data |
| Citations in Scopus | 4 - View on Scopus |
| Download/View statistics | View download statistics for this item |
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