Early intervention in bipolar disorders: clinical, biochemical and neuroimaging imperatives

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Berk, Michael, Malhi, Gin S, Hallam, Karen, Gama, C, Dodd, Seetal, Andreazza, A, Frey, B and Kapczinski, Flavio (2009) Early intervention in bipolar disorders: clinical, biochemical and neuroimaging imperatives. Journal of Affective Disorders, 114 (1-3). pp. 1-13. ISSN 0165-0327 (print) 1573-2517 (online)


In the absence of clear targets for primary prevention of many psychiatric illnesses, secondary prevention becomes the most feasible therapeutic target, and is best encompassed by the concept of early intervention. This construct encompasses the goals of minimising diagnostic delay and the prompt initiation of clinically appropriate therapy. This paper develops the rationale for early intervention in bipolar disorder. Three interrelated themes are discussed; the clinical data supporting the value of prompt diagnosis and treatment in bipolar disorder, the putative biochemical mechanisms underlying the pathophysiological processes, and the parallel concept of neuroprotection, and the developing neuroimaging data that supports early intervention. Early initiation of appropriate therapy may potentially facilitate improved clinical outcomes, and furthermight allow the secondary prevention of the sequelae of untreated illness, which include the deleterious impact on family relationships, psychosexual and vocational development, identity and self-concept and self-stigma.

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Item type Article
URI https://vuir.vu.edu.au/id/eprint/8533
DOI 10.1016/j.jad.2008.08.011
Official URL http://dx.doi.org/10.1016/j.jad.2008.08.011
Subjects Historical > FOR Classification > 1103 Clinical Sciences
Historical > FOR Classification > 1701 Psychology
Historical > Faculty/School/Research Centre/Department > School of Social Sciences and Psychology
Historical > SEO Classification > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions)
Keywords ResPubID19561. diagnosis, early intervention, mania, unipolar, neuroprotection, oxidative stress, Brain-derived neurotrophic factor, BDNF
Citations in Scopus 68 - View on Scopus
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