Abnormal dose-response melatonin suppression by light in bipolar type I patients compared with healthy adult subjects

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Hallam, Karen, Begg, Denovan P, Olver, James S and Norman, Trevor R (2009) Abnormal dose-response melatonin suppression by light in bipolar type I patients compared with healthy adult subjects. Acta Neuropsychiatrica, 21 (5). pp. 246-255. ISSN 0924-2708 (print) 1601-5215 (online)

Abstract

Among potential endophenotypes proposed for bipolar affective disorder focusing on circadian abnormalities associated with the illness has particularly high face validity. Melatonin sensitivity to light is one circadian endophenotype proposed as useful in bipolar disorder. The aim of this study was to investigate melatonin sensitivity to light over a range of light intensities in order to compare and contrast responses in bipolar I patients with those of healthy adult volunteers.

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Item type Article
URI https://vuir.vu.edu.au/id/eprint/8534
DOI https://doi.org/10.1111/j.1601-5215.2009.00416.x
Subjects Historical > Faculty/School/Research Centre/Department > School of Social Sciences and Psychology
Historical > FOR Classification > 1103 Clinical Sciences
Historical > SEO Classification > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions)
Keywords ResPubID19563. biological markers, bipolar disorder, eye, depression
Citations in Scopus 23 - View on Scopus
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