Hsp90α/β associates with the GSK3β/axin1/phospho-β-catenin complex in the human MCF-7 epithelial breast cancer model

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Cooper, Leanne, Prinsloo, Earl, Edkins, Adrienne L and Blatch, Gregory L (2011) Hsp90α/β associates with the GSK3β/axin1/phospho-β-catenin complex in the human MCF-7 epithelial breast cancer model. Biochemical and Biophysical Research Communications, 413 (4). pp. 550-554. ISSN 0006-291X

Abstract

Inhibition of the signal transduction chaperone, Hsp90α/β, may act in a similar manner to direct inhibition of GSK3β, which will stimulate Wnt/β-catenin signalling. The role of Hsp90α/β will need further investigation.

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Item type Article
URI https://vuir.vu.edu.au/id/eprint/8882
DOI https://doi.org/10.1016/j.bbrc.2011.08.136
Official URL http://www.sciencedirect.com/science/article/pii/S...
Subjects Historical > Faculty/School/Research Centre/Department > School of Biomedical and Health Sciences
Historical > FOR Classification > 0601 Biochemistry and Cell Biology
Historical > SEO Classification > 970111 Expanding Knowledge in the Medical and Health Sciences
Keywords ResPubID22939, Hsp90α/β, heat shock protein 90, GSK3β, glycogen synthase kinase 3β
Citations in Scopus 25 - View on Scopus
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