Screening for small molecule modulators of Hsp70 chaperone activity using protein aggregation suppression assays: inhibition of the plasmodial chaperone PfHsp70-1

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Cockburn, Ingrid L, Pesce, Eve-Rachele, Przyborski, Jude M, Davies-Coleman, Michael T, Clark, Peter G. K, Keyzers, Robert A, Stephens, Linda L and Blatch, Gregory L (2011) Screening for small molecule modulators of Hsp70 chaperone activity using protein aggregation suppression assays: inhibition of the plasmodial chaperone PfHsp70-1. Biological Chemistry, 392 (5). pp. 431-438. ISSN 1431-6730 (print) 1437-4316 (online)

Abstract

Two novel classes of small molecule inhibitors of PfHsp70-1 were identified in this study, one representing a new class of antiplasmodial compound (malonganenones). In addition to demonstrating the validity of PfHsp70-1 as a possible drug target, the compounds will potentially be useful as molecular probes for fundamental studies on Hsp70 chaperone function.

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Item type Article
URI https://vuir.vu.edu.au/id/eprint/9016
DOI https://doi.org/10.1515/BC.2011.040
Subjects Historical > Faculty/School/Research Centre/Department > School of Biomedical and Health Sciences
Historical > FOR Classification > 0601 Biochemistry and Cell Biology
Historical > SEO Classification > 970111 Expanding Knowledge in the Medical and Health Sciences
Keywords ResPubID23312, heat shock proteins, malaria, molecular chaparones, antiplasmodial compound
Citations in Scopus 40 - View on Scopus
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