Theiler's murine encephalomyelitis virus infection induces a redistribution of heat shock proteins 70 and 90 in BHK-21 cells, and is inhibited by novobiocin and geldanamycin

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Mutsvunguma, Lorraine Z, Moetlhoa, Boitumelo, Edkins, Adrienne L, Blatch, Gregory L, Knox, Caroline and Luke, Garry A (2011) Theiler's murine encephalomyelitis virus infection induces a redistribution of heat shock proteins 70 and 90 in BHK-21 cells, and is inhibited by novobiocin and geldanamycin. Cell Stress and Chaperones, 16 (5). pp. 505-515. ISSN 1355-8145

Abstract

This study describes the localisation of Hsps 70 and 90 in BHK-21 cells during Theiler's murine encephalomyelitis virus (TMEV) infection. In addition, the effect of Hsp90 inhibitors novobiocin and geldanamycin on the development of CPE and production of non-structural protein 2C was monitored over a 48 hour period. It is suggested that these chaperones play an important role in the lifecycle of TMEV.

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Item type Article
URI https://vuir.vu.edu.au/id/eprint/9018
DOI https://doi.org/10.1007/s12192-011-0262-x
Official URL http://link.springer.com/article/10.1007%2Fs12192-...
Subjects Historical > Faculty/School/Research Centre/Department > School of Biomedical and Health Sciences
Current > FOR Classification > 0601 Biochemistry and Cell Biology
Historical > SEO Classification > 970111 Expanding Knowledge in the Medical and Health Sciences
Keywords ResPubID23314, Theiler's murine encephalomyelitis virus (TMEV), encephalomyelitis virus infection, heat shock proteins, inhibitors, novobiocin, geldanamycin, cell chaperones, picornavirus, Hsp90 inhibitors, cytopathic effect
Citations in Scopus 5 - View on Scopus
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