The champions' mitochondria: is it genetically determined? A review on mitochondrial DNA and elite athletic performance

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Eynon, Nir ORCID: 0000-0003-4046-8276, Moran, Maria, Birk, Ruth and Lucia, Alejandro (2011) The champions' mitochondria: is it genetically determined? A review on mitochondrial DNA and elite athletic performance. Physiological Genomics, 43 (13). pp. 789-798. ISSN 1094-8341 (print) 1531-2267 (online)

Abstract

Aerobic ATP generation by the mitochondrial respiratory oxidative phosphorylation system (OXPHOS) is a vital metabolic process for endurance exercise. Notably, mitochondrial DNA (mtDNA) codifies 13 of the 83 polypeptides implied in the respiratory chain. As such, there is a strong rationale for identifying an association between mtDNA variants and “aerobic” (endurance) exercise phenotypes. The aim of this review is to summarize current knowledge on the association between mtDNA, nuclear genes involved in mitochondriogenesis, and elite endurance athletic status. Several studies in nonathletic people have demonstrated an association between certain mtDNA lineages and aerobic performance, characterized by maximal oxygen uptake(VO2MAX). Whether mtDNA haplogroups are also associated with the status of being an elite endurance athlete is more controversial, with differences between studies arising from the different ethnic backgrounds of the athletic cohorts (Caucasian of mixed geographic origin, Asiatic, or East African).

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Item type Article
URI https://vuir.vu.edu.au/id/eprint/9063
DOI https://doi.org/10.​1152/​physiolgenomics.​00029.​2011
Official URL http://physiolgenomics.physiology.org/content/43/1...
Subjects Historical > Faculty/School/Research Centre/Department > Institute of Sport, Exercise and Active Living (ISEAL)
Historical > FOR Classification > 1106 Human Movement and Sports Science
Historical > SEO Classification > 970111 Expanding Knowledge in the Medical and Health Sciences
Keywords ResPubID23437, elite athletes, genetics, exercise, genes, polymorphism, mitochondrial DNA, mtDNA, phenotypes, aerobic ATP generation
Citations in Scopus 34 - View on Scopus
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