Targeted Inactivation of Kinesin-1 in Pancreatic beta-Cells in Vivo Leads to Insulin Secretory Deficiency
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Cui, Ju, Wang, Zai, Cheng, Qianni, Lin, Raozhou, Zhang, Xinmei, Leung, Po sing, Copeland, Neal G, Jenkins, Nancy A, Yao, Kwokming and Huang, Jiandong (2011) Targeted Inactivation of Kinesin-1 in Pancreatic beta-Cells in Vivo Leads to Insulin Secretory Deficiency. Diabetes, 60 (1). pp. 320-330. ISSN 0012-1797
Abstract
Suppression of Kinesin-1 by antisense oligonucleotides, or overexpression of dominant-negative acting kinesin heavy chain, has been reported to affect the sustained phase of glucose-stimulated insulin secretion in β-cells in vitro. In this study, we examined the in vivo physiological role of Kinesin-1 in β-cell development and function.
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| Item type | Article |
| URI | https://vuir.vu.edu.au/id/eprint/9096 |
| DOI | 10.2337/db09-1078 |
| Official URL | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC301218... |
| Subjects | Historical > FOR Classification > 0601 Biochemistry and Cell Biology Historical > FOR Classification > 1101 Medical Biochemistry and Metabolomics Historical > SEO Classification > 970111 Expanding Knowledge in the Medical and Health Sciences Historical > Faculty/School/Research Centre/Department > Institute of Sport, Exercise and Active Living (ISEAL) |
| Keywords | ResPubID23495, kinesin, antisense oligonucleotides, insulin secretion |
| Citations in Scopus | 41 - View on Scopus |
| Download/View statistics | View download statistics for this item |
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