Targeted Inactivation of Kinesin-1 in Pancreatic beta-Cells in Vivo Leads to Insulin Secretory Deficiency

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Cui, Ju, Wang, Zai, Cheng, Qianni, Lin, Raozhou, Zhang, Xinmei, Leung, Po sing, Copeland, Neal G, Jenkins, Nancy A, Yao, Kwokming and Huang, Jiandong (2011) Targeted Inactivation of Kinesin-1 in Pancreatic beta-Cells in Vivo Leads to Insulin Secretory Deficiency. Diabetes, 60 (1). pp. 320-330. ISSN 0012-1797

Abstract

Suppression of Kinesin-1 by antisense oligonucleotides, or overexpression of dominant-negative acting kinesin heavy chain, has been reported to affect the sustained phase of glucose-stimulated insulin secretion in β-cells in vitro. In this study, we examined the in vivo physiological role of Kinesin-1 in β-cell development and function.

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Item type Article
URI https://vuir.vu.edu.au/id/eprint/9096
DOI https://doi.org/10.2337/db09-1078
Official URL http://www.ncbi.nlm.nih.gov/pmc/articles/PMC301218...
Subjects Historical > FOR Classification > 0601 Biochemistry and Cell Biology
Historical > FOR Classification > 1101 Medical Biochemistry and Metabolomics
Historical > SEO Classification > 970111 Expanding Knowledge in the Medical and Health Sciences
Historical > Faculty/School/Research Centre/Department > Institute of Sport, Exercise and Active Living (ISEAL)
Keywords ResPubID23495, kinesin, antisense oligonucleotides, insulin secretion
Citations in Scopus 40 - View on Scopus
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