Yeast Glycogen Synthase Kinase-3β Pathway Inhibitors from an Organic Extract of Streptomyces sp.
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Cheenpracha, Sarot, Zhang, Hao Lan, Mar, Anne M. N, Foss, Adam P, Foo, Sek Hin, Lai, Ngit Shin, Jee, Jap Meng, Seow, Heng-Fong, Ho, Coy Choke and Chang, Leng Chee (2009) Yeast Glycogen Synthase Kinase-3β Pathway Inhibitors from an Organic Extract of Streptomyces sp. Journal of Natural Products, 72 (8). pp. 1520-1523. ISSN 0163-3864
Abstract
Investigation of a microbial fermentation organic extract of Streptomyces sp. H7667 led to the isolation of three new imides, 3-[(5E)-5-methyl-4-oxo-2-hydroxy-5-octenyl]glutarimide (1), 2-amino-N-2′-(phenylacetyl)propanimide (5), and 2-amino-N-(2′-(cyclohex-2′′-enyl)acetyl)acetimide (6), and one new isoflavonoid glycoside, 6-O-methyl-7-O-Rrhamnopyranosyldaidzein (7), along with four known compounds. Their structures were elucidated by HRESIMS, 1H and 13C NMR, COSY, HMQC, HMBC, and NOESY spectra. Compounds 1-8 were evaluated for their inhibitory activities in the yeast glycogen synthase kinase-3� assay.
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| Item type | Article |
| URI | https://vuir.vu.edu.au/id/eprint/4220 |
| DOI | 10.1021/np900163f |
| Official URL | http://dx.doi.org/10.1021/np900163f |
| Subjects | Historical > Faculty/School/Research Centre/Department > School of Biomedical and Health Sciences Historical > FOR Classification > 1115 Pharmacology and Pharmaceutical Sciences |
| Keywords | ResPubID19142. yeast glycogen synthase kinase-3β pathway inhibitors, organic extract of streptomyces sp., microbial fermentation organic extract, imides, glutarimide, propanimide, acetyl acetimide, isoflavonoid glycoside |
| Citations in Scopus | 13 - View on Scopus |
| Download/View statistics | View download statistics for this item |
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