Neuroinflammatory modulation of extracellular vesicle biogenesis and cargo loading

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Spiers, Jereme G ORCID: 0000-0001-5872-8983, Vassileff, Natasha ORCID: 0000-0001-6554-4496 and Hill, Andrew F ORCID: 0000-0001-5581-2354 (2022) Neuroinflammatory modulation of extracellular vesicle biogenesis and cargo loading. NeuroMolecular Medicine, 24. pp. 385-391. ISSN 1535-1084

Abstract

Increasing evidence suggests neuroinflammation is a highly coordinated response involving multiple cell types and utilising several different forms of cellular communication. In addition to the well documented cytokine and chemokine messengers, extracellular vesicles (EVs) have emerged as key regulators of the inflammatory response. EVs act as vectors of intercellular communication, capable of travelling between different cells and tissues to deliver selectively packaged protein, miRNA, and lipids from the parent cell. During neuroinflammation, EVs transmit specific inflammatory mediators, particularly from microglia, to promote inflammatory resolution. This mini-review will highlight the novel neuroinflammatory mechanisms contributing to the biogenesis and selective packaging of EVs.

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Item type Article
URI https://vuir.vu.edu.au/id/eprint/45740
DOI 10.1007/s12017-022-08704-3
Official URL https://link.springer.com/article/10.1007/s12017-0...
Subjects Current > FOR (2020) Classification > 3101 Biochemistry and cell biology
Current > FOR (2020) Classification > 3204 Immunology
Current > Division/Research > Chancellery
Keywords neuroinflammation, brain health, extracellular vesicles, RNA
Citations in Scopus 5 - View on Scopus
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