Gene variants, such as creatine kinase (CK) polymorphisms,
have been suggested to explain the
inter-individual blood CK response to eccentric
exercise. However, since this association is still
doubtful, the purpose of this study was to analyse
the relationship between the magnitudes of
the CK response to exercise with the occurrence
of muscle CK-MM NcoI polymorphism in young
healthy subjects. Blood CK activity was assessed
in 70 subjects immediately before and 3, 24, 48,72, 96, 120, 168 h after strenuous eccentric exercise.
Based on the amount of CK release by each
subject, the sample was distributed in quartiles
and the genotype and allele frequency distribution
was compared among quartiles. Despite
the inter-individual variability of CK response
observed between subjects, there were no diff erences
in genotype and allele frequencies among
quartiles. The results allowed us to conclude that
CK response after exhaustive eccentric exercise is
not associated with CK-MM Ncol polymorphism.