Effects of exercise, renal disease, and digoxin on skeletal muscle Na+,K+-ATPase and related effects on plasma K+ and muscle performance

1528 643 1140 5 18354 document 1140 Petersen.pdf application/pdf 2600473 2011-09-09 10:21:55 https://vuir.vu.edu.au/1528/1/Petersen.pdf 1528 1 application/pdf text en public

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http://eprints.org/relation/isVersionOf https://vuir.vu.edu.au/id/dark_document/75610 http://eprints.org/relation/isVolatileVersionOf https://vuir.vu.edu.au/id/dark_document/75610 http://eprints.org/relation/issmallThumbnailVersionOf https://vuir.vu.edu.au/id/dark_document/75610 archive 116 disk0/00/00/15/28 2008-10-28 03:40:43 2021-08-27 07:41:38 2008-10-28 03:40:43 thesis show Petersen Aaron 0000-0003-1508-748X Effects of exercise, renal disease, and digoxin on skeletal muscle Na+,K+-ATPase and related effects on plasma K+ and muscle performance unpub 320000 HumanMovementRecreationPerformance skeletal muscle, physical exercise, renal disease, digoxin In skeletal muscle, the Na+,K+-ATPase enzyme regulates trans-membrane Na+ and K+ fluxes during contractions, and therefore also affects muscle excitability and plays an important role in delaying muscle fatigue. Consequently, any modulation of Na+,K+-ATPase content or activity has the potential to affect muscle fatiguability. Thus, this thesis investigated three factors thought to impair or down-regulate the skeletal muscle Na+,K+-ATPase – acute exercise, renal disease and digoxin. The related effects on plasma [K+] during exercise and on muscle performance were also examined. This thesis firstly investigated the acute effects of brief intense exercise on muscle Na+,K+-ATPase content and maximal activity (Study 1). Study 2 investigated the effects of end-stage renal disease on plasma [K+] regulation during exercise; examined the relationship between impaired [K+] regulation and muscle performance, and investigated the effects of endurance training in these patients. Study 3 investigated the impacts of end-stage renal disease and renal transplantation on skeletal muscle Na+,K+-ATPase and its relationship with muscle performance. Finally, Study 4 investigated the effects of chronic digoxin administration on skeletal muscle Na+,K+-ATPase content and maximal activity and on muscle performance in healthy humans. 2007 submitted 75610 2 2420233 dark_document 75610 Petersen, Aaron.pdf application/pdf 7eda33db340d8ebc2475aa8a4df5992f MD5 40809 2020-11-26 03:41:53 1528 3 3 application/pdf text VURR permission form en staffonly

Petersen, Aaron.pdf

other public 335 Victoria University Faculty of Arts, Education and Human Development phd Includes bibliographical references: pp. 235-292 FALSE