This thesis was an investigation of physical activity and the effects of exercise and autogenic training (AT) on the health-related quality of life (HRQOL) and psychological well-being of people with multiple sclerosis (MS). The terms HRQOL and psychological well-being in this thesis were operationally defined by the instruments used. The Multiple Sclerosis Quality of Life Instrument that includes constructs of physical, psychological, and social health measured HRQOL. Although psychological well-being is considered a component of HRQOL, measures of psychological well-being were extended by using the Centre for Epidemiological Studies Depression Scale, the Daily Hassles Scale, and the Profile of Mood States-Short Form.