Immediate and delayed nerve repair: improved muscle mass and function with leukemia inhibitory factor

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http://eprints.org/relation/isVersionOf https://vuir.vu.edu.au/id/dark_document/48571 http://eprints.org/relation/isVolatileVersionOf https://vuir.vu.edu.au/id/dark_document/48571 http://eprints.org/relation/ismediumThumbnailVersionOf https://vuir.vu.edu.au/id/dark_document/48571 48578 2 2371723 document 48578 small.jpg image/png 44a652e00f32aecd31295ce6d0f5fd59 MD5 2083 2020-05-20 01:54:07 https://vuir.vu.edu.au/1596/5/small.jpg 1596 5 5 image/png other Thumbnails conversion from text to thumbnail_small en staffonly

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http://eprints.org/relation/isVersionOf https://vuir.vu.edu.au/id/dark_document/48571 http://eprints.org/relation/isVolatileVersionOf https://vuir.vu.edu.au/id/dark_document/48571 http://eprints.org/relation/issmallThumbnailVersionOf https://vuir.vu.edu.au/id/dark_document/48571 68712 2 2408150 document 68712 lightbox.jpg image/png 7729865070d88452fc4ad30a76f2b56c MD5 60771 2020-10-09 03:10:46 https://vuir.vu.edu.au/1596/7/lightbox.jpg 1596 7 7 image/png other Thumbnails conversion from text to thumbnail_lightbox en staffonly

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http://eprints.org/relation/isVersionOf https://vuir.vu.edu.au/id/dark_document/68660 http://eprints.org/relation/isVolatileVersionOf https://vuir.vu.edu.au/id/dark_document/68660 http://eprints.org/relation/issmallThumbnailVersionOf https://vuir.vu.edu.au/id/dark_document/68660 archive 293 disk0/00/00/15/96 2008-11-11 02:17:23 2021-08-27 07:41:46 2008-11-11 02:17:23 article show Brown David L Brown, David L Bennett Timothy M Bennett, Timothy M Dowsing Bruce J Dowsing, Bruce J Hayes Alan 0000-0003-1398-3694 Abate Massimo Abate, Massimo Morrison Wayne A Morrison, Wayne A Immediate and delayed nerve repair: improved muscle mass and function with leukemia inhibitory factor pub 320000 BiomedicalSciences delayed nerve repair, leukemia inhibitory factor, muscle function In this study we examined the effect of leukemia inhibitory factor (LIF) on delayed repair of injured nerves. In a standard entubulation gap repair model of sciatic nerve in the rat, repair was performed immediately and after delays of 1 day, 1 week, and 4 weeks. Repaired nerves were treated with either LIF (10 ng) or saline, and assessment was by muscle mass and force contraction at 12 weeks after repair. After immediate nerve repair LIF administration resulted in 2.5- to 3-fold improvements compared with saline. In the 1-day delayed group, both saline and LIF treatment groups were comparable with that achieved with immediate repair combined with LIF. This result is consistent with the concept of preconditioning. In the 1-week delayed repair groups with LIF, muscle mass recovery and maximum force contraction were improved by 32% and 55%, respectively, compared with saline, whereas repairs delayed for 4 weeks showed increases of 50% and 36%. All delayed repairs treated with LIF were more effective than immediate repair with saline, but not as effective as primary repair with LIF. Our findings support the view that factors such as LIF may be efficacious for improving recovery of function in cases of delayed peripheral nerve repair. 2002-11 published WB Saunders Co. doi:10.1053/jhsu.2002.36518 http://dx.doi.org/10.1053/jhsu.2002.36518 48571 2 2371706 dark_document 48571 HayesCorrespondence.pdf application/pdf 15c0cbdd4e54bb68f83c6f19f60e3a66 MD5 24468 2020-05-20 01:43:47 1596 1 1 application/pdf text Author Correspondene en staffonly

HayesCorrespondence.pdf

other 68660 2 2408069 dark_document 68660 Hayes Alan.pdf application/pdf 140cb3769dfacd6e82e051fa41a7f1a0 MD5 44876 2020-10-09 03:00:38 1596 6 6 application/pdf text Generic Permission Form en staffonly

Hayes Alan.pdf

other none The journal of hand surgery (American volume) 27 6 1048-1055 TRUE 0363-5023 (Print) FALSE 9 2-s2.0-0036860347 2023-07-02 04:00:31