Macroeconomic competition between regions and countries has intensified dramatically in recent years, and as a result, selection of a favourable location and organisation of a logistics node plays an important role in determining a region’s ability to participate in emergent globalisation opportunities. Global connectivity of an area and its related industries, together with their ability to retain and further develop a ‘competitive advantage’, requires a significant review of the way in which a region interfaces with the rest of the world. The Logistics City-Cluster concept, which is one of the latest manifestations of a logistics node, is believed to be a suitable strategy to address these changes. However, whilst the Logistics City-Cluster is accepted by industry as a viable and unique concept, the nature of composition, characteristics and impact is still fragmented and very limited. The continued growth of this new strategy has made it imperative to develop a coherent knowledge base, ensuring future orderly development. Hence, this research was twofold: first, it sought to contribute to the theoretical knowledge of the common enabling elements of a Logistics City-Cluster and of their core influential factors; and secondly to explore the underlying assumptions that sustainable regional growth can be provided by such a concept.