There is a paucity of research on the mental health of asylum-seekers, particularly in comparison with refugee and migrant populations. Yet asylum-seekers occupy a vulnerable place in our community. After applying for a protection visa upon arrival in the host country, asylum-seekers frequently endure uncertainty for a protracted period as they traverse the Refugee Determination Process (RDP). The RDP in Australia and other Western countries can take years. Furthermore, asylum-seekers face psychosocial difficulties including numerous barriers to employment and access to health services, which can precipitate or perpetuate mental health problems. Despite this, little research has been undertaken with asylum-seekers negotiating the RDP, particularly studies employing a prospective design.