Signatures redacted and pdf attachment replaced. Thesis by publication. Articles which form chapters 3, 4, 11 not permitted. Removed and page inserted with citation. https://authorservices.wiley.com/author-resources/Journal-Authors/Promotion/article-sharing-policy.html Articles which form chapters 5, 6, 7, 8,10, 12 permitted as they have been made available under an Elsevier user license. Elsevier has a policy of allowing published articles to remain in theses. https://www.elsevier.com/about/policies/copyright/permissions (click on Can I include/use my article in my thesis/dissertation). Article which forms chapter 9 was removed - no permissions found that suggest it could be made open access through the repository. LM 16/10/2020