There is relatively little numerical study on the behavior of eccentrically loaded high strength rectangular concrete-filled steel tubular (CFST) slender beam-columns with large depth-to-thickness ratios, which may undergo local and global buckling. This paper presents a multiscale numerical model for simulating the interaction local and global buckling behavior of high strength thin-walled rectangular CFST slender beam-columns under eccentric loading. The effects of progressive local buckling are taken into account in the mesoscale model based on fiber element formulations. Computational algorithms based on the Muller