The synchronisation or entrainment of the brain to the local environment is managed by a system of internal ‘clock like’ cellular mechanisms (circadian system) that control the temporal organisation of the individual organism. Dysfunction of the circadian system is reflected in terms of temporal disorganisation observed in many aging individuals and in people with sleep disorders, jet-lag, and shift-lag. Research on the effects of chronic insomnia and circadian rhythms disorders, including; delayed sleep phase insomnia, jet lag and shift lag has shown that a
range of serious pathophysiological changes may occur over time...