This paper studies the role of international trade and openness in support of local
entrepreneurship in high growth enterprises in Vietnam during its fast development in
the past two decades. In addition to descriptive analysis of historical data, the paper
develops a new methodology, the endogenous enterprise growth model, to empirically
explore the major global engines and barriers to an enterprise growth. Best practice
policy for sustainable business development, regional co-operation and crisis
management is finally recommended for informed debate and policy implementation
analysis.